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Principal Investigator


Hongliang Li, M.D., Ph.D., Professor

Dr. Hongliang Li is a full professor of Medicine at Wuhan University. He currently serves as the Directors of Animal Research Center of Wuhan University, Collaborative Innovation Center of Model Animal, and Acting Director of Cardiovascular Research Institute of Wuhan University. After obtaining his Ph.D. degree from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Dr. Li pursued his post-doctoral trainings in Joslin Diabetes Center of Harvard Medical School and Department of Cardiology at the University of Toronto. He was selected as an awardee for Distinguished Young Scholars of National Nature Science Foundation Committee of China in 2014. In the past 15 years, he has published over 100 peer reviewed papers in high impact factor journals including Nature Communications, Circulation, Circulation Research, Hepatology, Journal of Hepatology, PNAS, Diabetes, Cell Death Differentions, Hypertension, and Cardiovascular Research. Since 2008, he has been funded for more than $ 20 million from Ministry of Science and Technology, Ministry of Education, and National Natural Science Foundation Committee of China. Currently, Dr. Li’s research interest focuses on defining the novel roles of innate immune network in cardiometabolic diseases. He is also interested in the development of biotechnology for genome manipulation and animal model of human diseases.


Dr. Zan Huang, Ph.D., Professor

Dr. Zan Huang is a full Professor of College of Life Sciences, Wuhan University. He graduated from Molecular Biology Program of Loyola University Chicago with a Ph.D. degree and continued his postdoctoral training in Chicago University and Northwestern University from 2006 to 2010. Dr. Huang has published more than 40 peer-reviewed papers on high impact factor journals including Journal of Clinic Investigation, Blood, Leukemia, CMLS, JBC, Journal of Immunology. He was selected as an awardee for Program for New Century Excellent Talents in University (NCET) of Ministry of Education of China and Chutian Scholar of Hubei Province. He is currently a member of American Society of Hematology. Dr. Huang’s research interest focuses on molecular mechanisms in leukemogenesis, hematopoiesis, and hepatic steatosis.


Scientific staff


Sijun Yang., Ph.D., Associate Professor

Dr. Sijun Yang is an associate professor of of the Center for Animal Experiment in Wuhan University. After he obtained his Ph.D in Animal Genetics and Breeding, he left China in 2003 and studied in USA. He did his postdoctoral training at Michigan University and Institute of Genetic medicine at Johns Hopokins University from 2005.6 to 2010.12. His major research interest combines biochemical, anatomical, molecular biology and transgenic animal model approaches to answer fundamental questions of mitophagy dysfunction in mtROS / NLRP3 inflammasome activation in the pathogenesis of type 2 diabetes. 



Ke Zhuang, M.D., Ph.D., Lecturer

Dr. Ke Zhuang is a lecturer of the Center for Animal Experiment and ABSL-3 Laboratory at Wuhan University. Dr. Zhuang obtained her M.D. and Ph.D. degrees from Wuhan University School of Medicine in 2002 and 2005. She worked in College of Life Sciences at Wuhan University during 2005-2008 and pursued her post-doctoral trainings in Aaron Diamond AIDS Research Center of Rockefeller University in New York from 2008 to 2012. Dr. Zhuang has been doing HIV/AIDS research for more than 10 years. Dr. Zhuang is currently interested in non-alcoholic steatohepatitis(NASH)and pathogenesis of HIV-Associated B- cell Lymphoma. 


Dr. Li ZHOU, Ph.D., Instructor of Medicine 

Dr. Li Zhou is an instructor of medicine in Center for Animal Experiment, Wuhan University. He graduated from College of Life Sciences, Wuhan University with Ph.D. degree in 2011 and continued his postdoctoral training in Wuhan University School of Medicine from 2012 to 2014.  Dr. Zhou’s research interest focuses on molecular mechanisms in acute lung disease and innate immunity.


Jianfeng Gao,Ph.D., Lecturer

Dr. Jianfeng Gao is a lecturer of the Center for Animal Experiment at Wuhan University. Dr. Gao graduated from Huazhong Agricultural University with a doctoral degree in June, 2014 and then pursued his post-doctoral trainings at Wuhan University School of Medicine from 2014 to 2016. Dr. Gao’s research interest focuses on molecular mechanism of nutritional metabolic disease.



Research Supporting


The research supporting team is mainly responsible for managing multiple technical platforms for research and service including Gene Modification Platform, Micromanipulation Platform, Animal Model Platform, Animal Management Platform, Pathology Analysis Platform, Cell Biology Platform, Informatization Platform, High-throughput Screening and Analysis Platform, and Molecular Detection Platform. These platforms aim to provide comprehensive, professional, and efficient technical support for investigators from universities, institutes, and hospitals majoring in the biomedical research.



Xin Zhang, supervisor of research supporting team, graduated from Huazhong Agricultural University with a master degree in animal genetics, breeding and reproduction. She has more than 6 years work experience in animal genetic engineering and related technical field. She is primarily responsible for the management of technical platforms for service.

E-mail: zhangxin57@whu.edu.cn



Gene Modification Platform creates new experimental animals and cell models by using transgenic technology, gene knockout/knock-in technology, viral transduction etc. to introduce, delete, or modify particular host gene. 



Jun Gong,director of gene modification platform, PhD candidate in College of Life Sciences in Wuhan University. He has more than 5 years work experience in molecular biology field. He is primarily responsible for creating new experimental animal and cell models and developing new gene modification technologies and animal models.

E-mail: gjun@whu.edu.cn



Yan Zhou, head of animal propagation group in gene modification platform, graduated from Huazhong Agricultural University    with a master degree in animal genetics, breeding and reproduction. She has 3 years work experience in genetic engineering. She is primarily responsible for vector construction and transcription test for gene modification and animal genotyping.

E-mail: zhouyanblue@webmail.hzau.edu.cn



Hui Zhou, head of virus-packaging group in gene modification platform, bachelor degree, more than 3 years work experience in gene modification area. She is mainly responsible for constructing and packaging lentivirus, adenovirus, and adeno-associated virus.

E-mail: lilab_mol@126.com




Tian Sun, technician, graduated from Hubei College of Traditional Chinese Medicine with a bachelor degree in food testing, more than 2 years work experience in molecular cloning area. She is primarily responsible for genotyping of newly developed animal strains for research.

E-mail: sylvie-yeyulinlin@foxmail.com




Jiao Liu, technician, graduated from Wuhan Institute of Bioengineering with a bachelor degree in biotechnology, more than 1 year work experience in molecular biology area. She is primarily responsible for identification of experimental animal conservation and breeding.

E-mail:ljshenxiaomo@foxmail.com



Yuan He, technician, graduated from Wuhan Institute of Bioengineering with a bachelor degree in bio-engineer,more than one year work experience in molecular biology area. She is primarily responsible for constructing vector for gene modification and transcription test.

E-mail:heyuanreal@foxmail.com




Micromanipulation Platform provides genetically modified animals and related technical services such as sperm freezing, embryo freezing, in vitro fertilization,strain depuration etc by microinjection and embryo transfer technologies.


Xin Chen, director of Micromanipulation Platform, graduated from Hubei College of Traditional Chinese Medicine with a bachelor degree in biotechnology, more than 5 years work experience in micro-operation. He is mainly responsible for pronuclear microinjection, embryo transplantation, sperm frozen, embryo frozen, and depuration of animal strains.

E-mail: 13995684028@163.com



Jun Tu, key technician of Micromanipulation Platform, graduated from Hubei University of Traditional Chinese Medicine with a bachelor degree in biotechnology, more than 4 years of micromanipulation research experience, expert in pronuclear microinjection and embryo transplantation.

E-mail: tujun0719@foxmail.com




Jun Zhang, key technician of Micromanipulation Platform, graduated from Hubei University of Traditional Chinese Medicine with a bachelor degree in biotechnology, more than 4 years of micromanipulation research experience. He is mainly responsible for pronuclear microinjection and embryo transplantation.

E-mail: 744356204@qq.com 


Animal Model Platform provides various animal models to reproduce similar pathological damages (function, metabolism, or morphology) to that in human diseases by artificially introducing pathogenic stimulus (physical, chemical, or biological interventions). These models may be valuable for study the etiology, prevention, and therapeutics of human diseases


Song Tian, director of Animal Model Platform, more than 5 years research experience of animal experiment. He is mainly responsible for establishing animal models, and skilled in vascular restenosis, liver ischemia/reperfusion injury, kidney ischemia/reperfusion injury, and heart transplantation.

E-mail:tians@whu.edu.cn



Rui Zhang, technician, more than 5 years research experience of animal experiment. He is skilled in rat and mice myocardial infarction model, cardiac ischemia/reperfusion injury, and ultrasonic inspection and measurement for rat and mice.

 



Xi Wang, technician, with more than 5 years research experience of animal experiment. She is mainly skilled in tumor models, such as intestinal cancer, gastric cancer, liver cancer, lung cancer, and carcinoma of urinary bladder

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Xiangjie Kong, technician, skilled in rat and mice cardiac hypertrophy models

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Qiang Wang, technician, skilled in rat and mice cardiac hypertrophy models, and hemodynamic measurement for rat and mice

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Qiaofang Wei, technician, mainly responsible for establishing diabetes model, atherosclerosis model, abdominal aneurysm model, and non-alcoholic fatty liver disease model. 





Cheng Du, technician, mainly responsible for establishing diabetes model, atherosclerosis model, abdominal aneurysm model, and non-alcoholic fatty liver disease model.

 




Shuo Xiong, technician, mainly responsible for establishing diabetes model, atherosclerosis model, abdominal aneurysm model, and non-alcoholic fatty liver disease model.






Ying Hong, technician, skilled in establishing rat and mice brain ischemia model.






Xiangyu Zhu, technician, skilled in establishing mice liver and kidney ischemia/reperfusion injury models.







Animal Management Platform aims to normalize and standardize the animal feeding based on the SPF conditions and provides the services for laboratory rodents such as strain depuration, live conservation, frozen conservation, strain breeding and expanding. Our platform has 600 strains of genetic engineer mice, and 100 strains of genetic engineer rats. 



Lin Wei, director of Animal Management Platform, graduated from Huazhong Agricultural University with a bachelor degree in veterinary science, more than 4 years of experience in animal feeding, breeding, and barrier system management. She is mainly responsible for management of the platform.

E-mail: 420101@whu.edu.cn



Yumei Wang, assistant of animal feeding group, with 10 years of experience in mice breeding and conservation. She is mainly responsible for animal feeding.

E-mail:2107751613@qq.com




Pei Li, assistant of animal feeding group, with 5 years of experience in working in barrier system and establishing genetic engineer animals. She is mainly responsible for the management of genetic animals.
E-mail:641271025@qq.com




Xia Chen, technician of genotyping, with 3 years of experience in genotyping. She is mainly responsible for genotyping all the genetic engineer animals. 

E-mail:1436599500@qq.com




Pathology Analysis Platform aims to examine the pathological changes occurring in different organs, tissues, or cell types. Major tasks include tissue processing (fixation, dehydration, embedding, and tissue section), staining (H&E, Immunofluorescence, and Immunohistochemistry), and observation.


Yan Zhang, director of Pathology Analysis Platform, bachelor degree in biotechnology with more than 5 years of research experience in this field. She is mainly responsible for staining and screening of pathological sections.

E-mail: zhangyan008@whu.edu.cn



Ling Yang, bachelor degree in biotechnology, more than 3 years of research experience in this field. She is mainly responsible for tissue processing and section preparation. 

E-mail: yangling_2009@sina.cn





Cell Biology Platform is to provide primary cells and cell lines for research, perform compound screen at cell level, and establish cell bank.



Ling Huang, director of Cell Biology Platform, master degree in biomedical engineering from Renmin Hospital of Wuhan University, more than 3 years of research experience in cell culture. She is mainly responsible for primary cell culture, cell model establishing, and establishing cell bank.

 



Yusang Su, technician of Cell Biology Platform, master degree IN biomedical engineering from Huazhong Agricultural University. She is mainly responsible for cell culture, cell model, and cell bank establishing

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Informatization Platform is responsible for informatizing management of genetic animals resources, animal model resources, plasmid resources, virus resources, cell resources, research data and, personnel archives and establishing related libraries to integrate various resources and insure the integrity and accuracy of research data.



Yaxing Zhang, Ph.D. degree in physiology from Sun Yat-sen University. He is responsible for informatization management of scientific data and resource library, and training and generalizing of experiment skill.

E-mail: zhangyxstar@whu.edu.cn




Xiaoling Li, with more than 2 years of experience in data administration. She is mainly responsible for data arrangement and preservation for our platform.

E-mail: 420106@whu.edu.cn





Li Zhang, master degree from Huazhong Agricultural University. She is mainly responsible for patent application and data arrangement of genetic animals. 

E-mail: nixinnin@163.com





High Throughput Screening Platform aims to identify genes, proteins and metabolites relevant to human diseases by using high throughput technologies including microarray, RNA-seq, protomics, and metabonomics. Thus we try to systemically elucidate possible mechanisms underlying the pathogenesis of human diseases at gene expression, protein expression, and metabolite levels, which will provide powerful clue and idea for our research group. This platform also aims to mine high throughput data of the lab and public available database to search the novel target molecules relevant to human diseases and provide inexhaustible stimulus for our research group. 



Peng Zhang, director of High Throughput Screening and Analysis Platform, Ph.D. degree in genetics, graduated from Medical School of Shanghai Jiaotong University. He focuses on metabolic diseases and has published several papers in Circ Res, J Hepatol and Nat Commun etc. He is responsible for managing the high throughput data, experiment designing, and  customized analysis of data. He also develops novel workflow and technology for high throughput data analysis.

                               E-mail:zhp@whu.edu.cn



Molecular Detection Platform is responsible for quantitative analysis of protein and mRNA expression. 



Xueyong Zhu, director of Molecular Detection Platform, bachelor degree in biotechnology, more than 3 years of experience in protein and mRNA detection. 
E-mail:zhuxueyong@foxmail.com





Xin Liao, junior college degree, 2 year experience in protein detection.
E-mail:liaoxin8820@vip.qq.com






Postdoctoral fellow


Guangnian Zhao, Ph.D. 
Guangnian Zhao graduated from Peking Union Medical College and Chinese Academy of Medical Sciences with a Ph.D. degree in 2013.
E-mail: zhaogn@whu.edu.cn


Peng Zhang, Ph.D. 
Peng Zhang is a postdoctoral student in the laboratory. He recently obtained his Ph.D. from Shanghai Jiaotong University in 2014.
E-mail: zhp@whu.edu.cn


Junhong Guo, Ph.D. 
Junhong Guo is a postdoctoral student in the laboratory. She has recently obtained her Ph.D. from Wuhan University in 2014.
E-mail: guojunhong@whu.edu.cn


Yanxiao Ji, Ph.D. 
Yanxiao Ji is a postdoctoral student in the laboratory. He has recently graduated from Wuhan University with a Ph.D. in 2015.
E-mail: jiyanxiao@whu.edu.cn


Yaxing Zhang, Ph.D. 
Yaxing Zhang recently graduated with a Ph.D. from Sun Yat-sen University.
E-mail: zhangyxstar@whu.edu.cn



Chun Fang, Ph.D.
Chun got his doctoral degree from the Institute of Preventive Veterinary Medicine of Zhejiang University in 2015.
E-mail: fangchun@whu.edu.cn



Wenzhe Mao, Ph.D.
Mao Wenzhe graduated with Ph.D. from Chinese Academy of Medical Sciences &Peking Union Medical College.
E-mail: maowzhdy@whu.edu.cn




Ph.D. candidate


Xi Jiang,
Ph.D. Candidate
Xi Jiang is currently a Ph.D. candidate in Cardiology Department of the Renmin Hospital of Wuhan University.
E-mail: jerryson85@whu.edu.cn



Pixiao Wang,
Ph.D. Candidate
Pixiao Wang is currently a Ph.D. candidate in Cardiology Department of the Renmin Hospital of Wuhan University. 
E-mail: wangpx@whu.edu.cn



Jun Gong, B.Sc. 
Ph.D. Candidate
Jun Gong is now a Ph.D. candidate in College of Life Sciences at the Wuhan University.
E-mail: gjun@whu.edu.cn



Wenlin Cheng, 
Ph.D. Candidate
Wenlin cheng is currently a Ph.D. student in Cardiology Department of Renmin Hospital of Wuhan University.
E-mail: chengwenlin@whu.edu.cn



Xiaozhan Wang,
Ph.D. Candidate
Xiaozhan Wang is currently a Ph.D. in Cardiology Department of Renmin Hospital of Wuhan University.
E-mail: wangxz@whu.edu.cn



Zhou Jiang, B.Sc.
Ph.D. Candidate
Zhou Jiang is a Ph.D. student in College of Life Science at Wuhan University.
E-mail: joe5130lab@whu.edu.cn




Fengjuan Yan, B.Sc.
Ph.D. Candidate
Fengjuan Yan is a Ph.D. student in the College of Life Sciences of Wuhan University.
E-mail: yanfengjuan1026@163.com




Yi Ren,
Ph.D. Candidate
Yi Ren is a Ph.D. student in College of Life Science of Wuhan University.
E-mail: ren.yi@whu.edu.cn





Master candidate


Min Wang, B.Sc. 
Master Candidate
Min Wang is a graduate student in College of Life Sciences at Wuhan University.
E-mail: wangmin1993@whu.edu.cn



Wanlin Qiu, B.Sc.
Master Candidate
Wanlin Qiu is a graduate student in the College of Life Sciences at Wuhan University. 
E-mail: qwanlin2015@whu.edu.cn




Keqiong Deng,
Master candidate
Keqiong Deng is currently a Master candidate in Cardiology Department of Renmin Hospital of Wuhan University.
E-mail: dengkeqiong@whu.edu.cn



Junfei Hu,
Master candidate
Junfei Hu is currently Master student in Cardiology Department of Renmin Hospital of Wuhan University.

E-mail: hujunfei@whu.edu.cn



Juanjuan Qin,
Master candidate
Master student in Cardiology Department of Renmin Hospital of Wuhan University.
E-mail: qinjuanjuan@whu.edu.cn




Lijun Shen, 
Master candidate
Lijun Shen is currently a Master student in Cardiology Department of Renmin Hospital of Wuhan University.
E-mail: shenlijun@whu.edu.cn



Lingping Zhao,
Master candidate
Lingping Zhao is now a Master student in Cardiology Department of Medical Research Institute at Wuhan University.
E-mail: blingping@whu.edu.cn



Wenxin Wang,
Master candidate
Wenxin Wang is now a Master student in Cardiology Department of Medical Research Institute at Wuhan University.
E-mail: wangwenxin@whu.edu.cn



Zhenzhen Yan, B.Sc. 
Master Candidate
Zhenzhen Yan is a graduate student in College of Life Sciences at Wuhan University. 
E-mail: yanzhzh@whu.edu.cn




Cuijuan Han, B.Sc. 
Master Candidate
Cuijuan Han is a graduate student in College of Life Sciences at Wuhan University.
E-mail: hancuijuan@whu.edu.cn